This affirmation is not aimed at those who, through no fault of their own, do not know Christ and his Church: Those who, through no fault of their own, do not know the Gospel of Christ or his Church, but who nevertheless seek God with a sincere heart, and, moved by grace, try in their actions to do his will as they know it through the dictates of their conscience—those too may achieve eternal salvation.
Catholics believe that the Virgin Mary, the Mother of God, alone of all human beings, was not affected by original sin and remained sinless throughout her life. Read more here. Excerpt: “The Immaculate Conception means that Mary … was conceived without original sin or its stain—that’s what “immaculate” means: without stain. The essence of original sin consists in the deprivation of sanctifying grace, and its stain is a corrupt nature. Mary was preserved from these defects by God’s grace; from the first instant of her existence she was in the state of sanctifying grace and was free from the corrupt nature original sin brings.”